Sequence Detail

ID/Version

Q64299 Q8CA67 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=CCN family member 3 {ECO:0000305};AltName: Full=Cellular communication network factor 3 {ECO:0000250|UniProtKB:P48745};AltName: Full=Nephroblastoma-overexpressed gene protein homolog;AltName: Full=Protein NOV homolog; Short=NovH;Flag

Provider

SWISS-PROT

Sequence

Polypeptide 354 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ccn3	cellular communication network factor 3	79	107	2	11

Sequence references in MGI

J:37706 Snaith MR, et al., Genomic structure and chromosomal mapping of the mouse nov gene. Genomics. 1996 Dec 15;38(3):425-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:172144 Shimoyama T, et al., CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration. Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):675-82
J:199662 Matsushita Y, et al., CCN3 protein participates in bone regeneration as an inhibitory factor. J Biol Chem. 2013 Jul 5;288(27):19973-85
J:202162 Paradis R, et al., Nov/Ccn3, a novel transcriptional target of FoxO1, impairs pancreatic beta-cell function. PLoS One. 2013;8(5):e64957
J:215090 Liu J, et al., Overexpression of CCN3 inhibits inflammation and progression of atherosclerosis in apolipoprotein E-deficient mice. PLoS One. 2014;9(4):e94912
J:224744 Sakamoto K, et al., The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway. J Biol Chem. 2002 Aug 16;277(33):29399-405
J:352591 Babey ME, et al., A maternal brain hormone that builds bone. Nature. 2024 Aug;632(8024):357-365