Sequence Detail

ID/Version

Q64321 Q80VV5 (UniProt | EBI)

Last sequence update: 2004-08-16
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Zinc finger and BTB domain-containing protein 7B {ECO:0000305};AltName: Full=Krueppel-related zinc finger protein cKrox; Short=c-Krox;AltName: Full=T-helper-inducing POZ/Krueppel-like factor;AltName: Full=Zinc finger protein 67;

Provider

SWISS-PROT

Sequence

Polypeptide 544 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Zbtb7b	zinc finger and BTB domain containing 7B	41	105	3	45

Sequence references in MGI

J:20520 Galera P, et al., c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9372-6
J:95867 He X, et al., The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature. 2005 Feb 24;433(7028):826-33
J:131081 Setoguchi R, et al., Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science. 2008 Feb 8;319(5864):822-5
J:164308 Zhang M, et al., p300-mediated acetylation stabilizes the Th-inducing POK factor. J Immunol. 2010 Oct 1;185(7):3960-9
J:189792 Rui J, et al., Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation. J Immunol. 2012 Aug 1;189(3):1380-90
J:190672 Enders A, et al., ZBTB7B (Th-POK) regulates the development of IL-17-producing CD1d-restricted mouse NKT cells. J Immunol. 2012 Dec 1;189(11):5240-9
J:195348 Tanaka H, et al., Epigenetic Thpok silencing limits the time window to choose CD4(+) helper-lineage fate in the thymus. EMBO J. 2013 Apr 17;32(8):1183-94
J:244072 Li S, et al., Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis. Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7111-E7120
J:258710 Luckey MA, et al., The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling. Nat Immunol. 2014 Jul;15(7):638-45
J:259304 Zhang R, et al., Th-POK regulates mammary gland lactation through mTOR-SREBP pathway. PLoS Genet. 2018 Feb;14(2):e1007211