ID/Version |
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Sequence description from provider |
RecName: Full=Tumor suppressor ARF {ECO:0000305};AltName: Full=Alternative reading frame; Short=ARF;AltName: Full=Cyclin-dependent kinase inhibitor 2A;AltName: Full=p19ARF; | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
169
aa
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Source | |||||||||||||||
Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:38065
Herzog CR, et al., Sequence variation and chromosomal mapping of the murine Cdkn2a tumor suppressor gene. Mamm Genome. 1997 Jan;8(1):65-6
J:41563 Quelle DE, et al., Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell. 1995 Dec 15;83(6):993-1000 J:44427 Kamijo T, et al., Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell. 1997 Nov 28;91(5):649-59 J:54019 Inoue K, et al., Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3993-8 J:61786 Melendez B, et al., Characterization of the murine p19(ARF) promoter CpG island and its methylation pattern in primary lymphomas. Carcinogenesis. 2000 Apr;21(4):817-21 J:63444 Inoue K, et al., Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis. Genes Dev. 2000 Jul 15;14(14):1797-809 J:79357 Hasan MK, et al., CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. J Biol Chem. 2002 Oct 4;277(40):37765-70 J:91428 Yi Y, et al., p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development. Mol Biol Cell. 2004 May;15(5):2302-11 J:93211 Qi Y, et al., p19ARF directly and differentially controls the functions of c-Myc independently of p53. Nature. 2004 Oct 7;431(7009):712-7 J:94162 Suzuki H, et al., The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression. Biochem Biophys Res Commun. 2004 Dec 31;326(1):242-8 J:111292 Reef S, et al., A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. Mol Cell. 2006 May 19;22(4):463-75 J:126002 Mallakin A, et al., Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. Cancer Cell. 2007 Oct;12(4):381-94 J:127208 Tompkins VS, et al., A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. J Biol Chem. 2007 Jan 12;282(2):1322-33 J:162926 Lessard F, et al., The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I. Mol Cell. 2010 May 28;38(4):539-50 J:189986 Reef S, et al., The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein. Oncogene. 2007 Oct 11;26(46):6677-83 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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