Sequence Detail

ID/Version

Q64429 Q3UVA8 Q60593 Q64461 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Cytochrome P450 1B1 {ECO:0000303|PubMed:15258110}; EC=1.14.14.1 {ECO:0000269|PubMed:23821647};AltName: Full=CYPIB1;AltName: Full=Cytochrome P450CMEF; Short=Cytochrome P450EF;AltName: Full=Hydroperoxy icosatetraenoate dehydrat

Provider

SWISS-PROT

Sequence

Polypeptide 543 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cyp1b1	cytochrome P450, family 1, subfamily b, polypeptide 1	90	109	3	7

Sequence references in MGI

J:16460 Shen Z, et al., Identification of a cytochrome P450 gene by reverse transcription--PCR using degenerate primers containing inosine. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11483-7
J:18333 Savas U, et al., Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression. J Biol Chem. 1994 May 27;269(21):14905-11
J:20000 Shen Z, et al., cDNA cloning, sequence analysis, and induction by aryl hydrocarbons of a murine cytochrome P450 gene, Cyp1b1. DNA Cell Biol. 1994 Jul;13(7):763-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:144041 Tang Y, et al., CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression. Blood. 2009 Jan 15;113(3):744-54
J:157662 Tang Y, et al., CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress. Am J Physiol Cell Physiol. 2010 Mar;298(3):C665-78
J:197371 Palenski TL, et al., Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells. Lab Invest. 2013 Jun;93(6):646-62
J:203227 Dong H, et al., Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins. Biochem Biophys Res Commun. 2013 Jun 14;435(4):727-32
J:205425 Zhao Y, et al., Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress. Mol Cell Biol. 2013 Nov;33(21):4225-40
J:210924 Choudhary D, et al., Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Drug Metab Dispos. 2004 Aug;32(8):840-7
J:211385 Nishida CR, et al., Specificity determinants of CYP1B1 estradiol hydroxylation. Mol Pharmacol. 2013 Sep;84(3):451-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89