Sequence Detail

ID/Version

Q64434 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Protein-tyrosine kinase 6; EC=2.7.10.2;AltName: Full=SRC-related intestinal kinase;

Provider

SWISS-PROT

Sequence

Polypeptide 451 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ptk6	PTK6 protein tyrosine kinase 6	38	102	4	7

Sequence references in MGI

J:22508 Vasioukhin V, et al., A novel intracellular epithelial cell tyrosine kinase is expressed in the skin and gastrointestinal tract. Oncogene. 1995 Jan 19;10(2):349-57
J:56362 Llor X, et al., BRK/Sik expression in the gastrointestinal tract and in colon tumors. Clin Cancer Res. 1999 Jul;5(7):1767-77
J:84567 Derry JJ, et al., Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells. Oncogene. 2003 Jul 3;22(27):4212-20
J:95160 Haegebarth A, et al., The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2. J Biol Chem. 2004 Dec 24;279(52):54398-404
J:110331 Haegebarth A, et al., Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine. Mol Cell Biol. 2006 Jul;26(13):4949-57