Sequence Detail

ID/Version

Q64702 Q80UT6 Q78EG6 Q8R0I5 Q9CVU6 Q3UVA3 Q6PEP6 Q9CVR6 (UniProt | EBI)

Last sequence update: 2004-08-16
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase PLK4 {ECO:0000305}; EC=2.7.11.21 {ECO:0000250|UniProtKB:O00444};AltName: Full=Polo-like kinase 4; Short=PLK-4;AltName: Full=Serine/threonine-protein kinase 18;AltName: Full=Serine/threonine-pro

Provider

SWISS-PROT

Sequence

Polypeptide 925 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Plk4	polo like kinase 4	37	100	3	17

Sequence references in MGI

J:19189 Fode C, et al., Sak, a murine protein-serine/threonine kinase that is related to the Drosophila polo kinase and involved in cell proliferation. Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6388-92
J:35592 Fode C, et al., Constitutive expression of murine Sak-a suppresses cell growth and induces multinucleation. Mol Cell Biol. 1996 Sep;16(9):4665-72
J:68142 Hudson JW, et al., Late mitotic failure in mice lacking Sak, a polo-like kinase. Curr Biol. 2001 Mar 20;11(6):441-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100110 Ko MA, et al., Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis. Nat Genet. 2005 Aug;37(8):883-8
J:152657 Martindill DM, et al., Nucleolar release of Hand1 acts as a molecular switch to determine cell fate. Nat Cell Biol. 2007 Oct;9(10):1131-41
J:203522 Zhao H, et al., The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Nat Cell Biol. 2013 Dec;15(12):1434-44