Sequence Detail

ID/Version

Q66JW3 Q8BKH9 Q8BYQ5 Q8R4H0 (UniProt | EBI)

Last sequence update: 2006-06-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Thymocyte selection-associated high mobility group box protein TOX {ECO:0000303|PubMed:11850626};AltName: Full=Thymus high mobility group box protein TOX {ECO:0000303|PubMed:11850626};

Provider

SWISS-PROT

Sequence

Polypeptide 526 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tox	thymocyte selection-associated high mobility group box	22	108	3	14

Sequence references in MGI

J:74993 Wilkinson B, et al., TOX: an HMG box protein implicated in the regulation of thymocyte selection. Nat Immunol. 2002 Mar;3(3):272-80
J:91035 Aliahmad P, et al., TOX Provides a Link Between Calcineurin Activation and CD8 Lineage Commitment. J Exp Med. 2004 Apr 19;199(8):1089-99
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:131287 Aliahmad P, et al., Development of all CD4 T lineages requires nuclear factor TOX. J Exp Med. 2008 Jan 21;205(1):245-56
J:164687 Aliahmad P, et al., Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages. Nat Immunol. 2010 Oct;11(10):945-52
J:220033 Artegiani B, et al., Tox: a multifunctional transcription factor and novel regulator of mammalian corticogenesis. EMBO J. 2015 Apr 1;34(7):896-910
J:232838 Seehus CR, et al., The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor. Nat Immunol. 2015 Jun;16(6):599-608
J:282948 Khan O, et al., TOX transcriptionally and epigenetically programs CD8(+) T cell exhaustion. Nature. 2019 Jul;571(7764):211-218
J:283414 Scott AC, et al., TOX is a critical regulator of tumour-specific T cell differentiation. Nature. 2019 Jul;571(7764):270-274