Sequence Detail

ID/Version

Q6DIB5 Q3TLU3 Q3UG73 (UniProt | EBI)

Last sequence update: 2004-08-16
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Multiple epidermal growth factor-like domains protein 10 {ECO:0000312|MGI:MGI:2685177}; Short=Multiple EGF-like domains protein 10;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1147 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Megf10	multiple EGF-like-domains 10	35	109	3	8

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:164422 Singh TD, et al., MEGF10 functions as a receptor for the uptake of amyloid-beta. FEBS Lett. 2010 Sep 24;584(18):3936-42
J:182578 Kay JN, et al., MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons. Nature. 2012 Mar 22;483(7390):465-9
J:183964 Holterman CE, et al., Megf10 regulates the progression of the satellite cell myogenic program. J Cell Biol. 2007 Dec 3;179(5):911-22
J:231811 Iram T, et al., Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes. J Neurosci. 2016 May 11;36(19):5185-92
J:241480 Suzuki E, et al., MEGF10 is a mammalian ortholog of CED-1 that interacts with clathrin assembly protein complex 2 medium chain and induces large vacuole formation. Exp Cell Res. 2007 Oct 15;313(17):3729-42
J:241496 Saha M, et al., Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions. Hum Mol Genet. 2017 Aug 1;26(15):2984-3000