Sequence Detail

ID/Version

Q6P549 Q9JLL7 Q80YB9 O08611 Q0VDX5 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 {ECO:0000305}; EC=3.1.3.86 {ECO:0000269|PubMed:10958682};AltName: Full=Inositol polyphosphate phosphatase-like protein 1 {ECO:0000250|UniProtKB:O15357}; Short=INPPL-1 {

Provider

SWISS-PROT

Sequence

Polypeptide 1257 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Inppl1	inositol polyphosphate phosphatase-like 1	57	103	3	21

Sequence references in MGI

J:51726 Yamabhai M, et al., Examining the specificity of Src homology 3 domain--ligand interactions with alkaline phosphatase fusion proteins. Anal Biochem. 1997 Apr 5;247(1):143-51
J:59977 Schurmans S, et al., The mouse SHIP2 (Inppl1) gene: complementary DNA, genomic structure, promoter analysis, and gene expression in the embryo and adult mouse. Genomics. 1999 Dec 1;62(2):260-71
J:96048 Sleeman MW, et al., Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. Nat Med. 2005 Feb;11(2):199-205
J:96443 Clement S, et al., The lipid phosphatase SHIP2 controls insulin sensitivity. (Erratum: Nature 2004 Oct 14;4131(7010):878). Nature. 2001 Jan 4;409(6816):92-7
J:126616 Ai J, et al., The inositol phosphatase SHIP-2 down-regulates FcgammaR-mediated phagocytosis in murine macrophages independently of SHIP-1. Blood. 2006 Jan 15;107(2):813-20
J:172725 Hasegawa J, et al., SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain. J Cell Biol. 2011 May 30;193(5):901-16
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89