Sequence Detail

ID/Version

Q6PEM8 Q571I8 Q8R1H7 Q5SYG0 Q9D1P1 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Proton-coupled folate transporter {ECO:0000303|PubMed:21346251};AltName: Full=Heme carrier protein 1 {ECO:0000303|PubMed:16143108};AltName: Full=PCFT/HCP1 {ECO:0000250|UniProtKB:Q96NT5};AltName: Full=Solute carrier family 46 member 1 {ECO:00

Provider

SWISS-PROT

Sequence

Polypeptide 459 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc46a1	solute carrier family 46, member 1	31	99	3	11

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:122693 Shayeghi M, et al., Identification of an intestinal heme transporter. Cell. 2005 Sep 9;122(5):789-801
J:127097 Umapathy NS, et al., Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types. Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5299-305
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:173282 Salojin KV, et al., A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency. Blood. 2011 May 5;117(18):4895-904
J:191392 Gnana-Prakasam JP, et al., Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis. Invest Ophthalmol Vis Sci. 2011 Nov;52(12):9279-86
J:319976 Zhao R, et al., A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis. J Biol Chem. 2009 Feb 13;284(7):4267-74