Sequence Detail

ID/Version

Q6PHS9 Q3TPT9 Q920H5 Q9EQG2 B2RY16 Q8C8R8 Q920H6 Q8CHE9 Q3TSS6 Q6REE3 Q9R142 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Voltage-dependent calcium channel subunit alpha-2/delta-2;AltName: Full=Protein ducky;AltName: Full=Voltage-gated calcium channel subunit alpha-2/delta-2;Contains: RecName: Full=Voltage-dependent calcium channel subunit alpha-2-2;Contains:

Provider

SWISS-PROT

Sequence

Polypeptide 1154 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cacna2d2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	21	115	4	16

Sequence references in MGI

J:66071 Barclay J, et al., Genomic organization of the mouse and human alpha2delta2 voltage-dependent calcium channel subunit genes. Mamm Genome. 2000 Dec;11(12):1142-4
J:70845 Barclay J, et al., Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells. J Neurosci. 2001 Aug 15;21(16):6095-104
J:75072 Brodbeck J, et al., The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated alpha 2 delta-2 protein with abnormal function. J Biol Chem. 2002 Mar 8;277(10):7684-93
J:86755 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2002 Oct 31;9(5):179-88
J:88967 Brill J, et al., entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse. J Biol Chem. 2004 Feb 20;279(8):7322-30
J:92396 Ivanov SV, et al., Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene. Am J Pathol. 2004 Sep;165(3):1007-18
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:111891 Davies A, et al., The calcium channel alpha2delta-2 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function. J Neurosci. 2006 Aug 23;26(34):8748-57
J:116185 Donato R, et al., The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression. J Neurosci. 2006 Nov 29;26(48):12576-86
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89