Sequence Detail

ID/Version

Q6S5J6 Q6VSV2 Q8C9Q6 Q9EPY2 Q9ERH0 Q7TPR8 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Krev interaction trapped protein 1; Short=Krev interaction trapped 1;AltName: Full=Cerebral cavernous malformations 1 protein homolog;

Provider

SWISS-PROT

Sequence

Polypeptide 736 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Krit1	KRIT1, ankyrin repeat containing	39	101	4	11

Sequence references in MGI

J:66942 Zhang J, et al., Cloning of the Murine Krit1 cDNA Reveals Novel Mammalian 5' Coding Exons. Genomics. 2000 Dec 15;70(3):392-5
J:87914 Retta SF, et al., Identification of Krit1B: a novel alternative splicing isoform of cerebral cavernous malformation gene-1. Gene. 2004 Jan 21;325:63-78
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:146528 Kleaveland B, et al., Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med. 2009 Feb;15(2):169-76
J:163084 Goitre L, et al., KRIT1 regulates the homeostasis of intracellular reactive oxygen species. PLoS One. 2010;5(7):e11786
J:170021 Wustehube J, et al., Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12640-5
J:170050 Lampugnani MG, et al., CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci. 2010 Apr 1;123(Pt 7):1073-80
J:229615 Marchi S, et al., Defective autophagy is a key feature of cerebral cavernous malformations. EMBO Mol Med. 2015 Nov;7(11):1403-17