Sequence Detail

ID/Version

Q6SJE0 Q6SJD9 (UniProt | EBI)

Last sequence update: 2004-08-16
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=GDNF family receptor alpha-like;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 393 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gfral	GDNF family receptor alpha like	37	96	3	19

Sequence references in MGI

J:251850 Emmerson PJ, et al., The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL. Nat Med. 2017 Oct;23(10):1215-1219
J:251855 Mullican SE, et al., GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates. Nat Med. 2017 Oct;23(10):1150-1157
J:251981 Yang L, et al., GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand. Nat Med. 2017 Oct;23(10):1158-1166
J:254140 Hsu JY, et al., Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15. Nature. 2017 Oct 12;550(7675):255-259
J:292147 Coll AP, et al., GDF15 mediates the effects of metformin on body weight and energy balance. Nature. 2020 Feb;578(7795):444-448
J:298668 Worth AA, et al., The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling. Elife. 2020 Jul 29;9:e55164
J:316128 Sabatini PV, et al., GFRAL-expressing neurons suppress food intake via aversive pathways. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2021357118
J:325215 Suriben R, et al., Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice. Nat Med. 2020 Aug;26(8):1264-1270
J:340165 Wang D, et al., GDF15 promotes weight loss by enhancing energy expenditure in muscle. Nature. 2023 Jul;619(7968):143-150
J:342573 Lu JF, et al., Camptothecin effectively treats obesity in mice through GDF15 induction. PLoS Biol. 2022 Feb;20(2):e3001517