Sequence Detail

ID/Version

Q6VV64 Q1LZM8 Q3MI50 Q1LZJ5 Q3MI51 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Potassium channel subfamily K member 18;AltName: Full=Two-pore-domain potassium channel TRESK {ECO:0000303|PubMed:14981085};

Provider

SWISS-PROT

Sequence

Polypeptide 394 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kcnk18	potassium channel, subfamily K, member 18	19	97	3	8

Sequence references in MGI

J:90661 Czirjak G, et al., The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin. J Biol Chem. 2004 Apr 30;279(18):18550-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113483 Czirjak G, et al., Targeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K+ channel, TRESK. J Biol Chem. 2006 May 26;281(21):14677-82
J:137564 Czirjak G, et al., Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation. J Biol Chem. 2008 Jun 6;283(23):15672-80
J:139352 Bautista DM, et al., Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels. Nat Neurosci. 2008 Jul;11(7):772-9
J:166001 Egenberger B, et al., N-linked glycosylation determines cell surface expression of two-pore-domain K+ channel TRESK. Biochem Biophys Res Commun. 2010 Jan 8;391(2):1262-7
J:175137 Dobler T, et al., TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones. J Physiol. 2007 Dec 15;585(Pt 3):867-79
J:270313 Royal P, et al., Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK. Neuron. 2019 Jan 16;101(2):232-245.e6
J:298729 Lengyel M, et al., TRESK and TREK-2 two-pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons. J Biol Chem. 2020 Aug 28;295(35):12408-12425
J:352581 Ruck T, et al., K(2P)18.1 translates T cell receptor signals into thymic regulatory T cell development. Cell Res. 2022 Jan;32(1):72-88