Sequence Detail

ID/Version

Q6YGZ1 Q8K3K3 B2RS99 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Heparanase; EC=3.2.1.166;AltName: Full=Endo-glucoronidase;Contains: RecName: Full=Heparanase 8 kDa subunit;Contains: RecName: Full=Heparanase 50 kDa subunit;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 535 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hpse	heparanase	50	101	3	15

Sequence references in MGI

J:56032 Hulett MD, et al., Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis [see comments]. Nat Med. 1999 Jul;5(7):803-9
J:81602 Miao HQ, et al., Cloning, expression, and purification of mouse heparanase. Protein Expr Purif. 2002 Dec;26(3):425-31
J:97080 Zcharia E, et al., Heparanase regulates murine hair growth. Am J Pathol. 2005 Apr;166(4):999-1008
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:124228 Ben-Zaken O, et al., Heparanase induces Akt phosphorylation via a lipid raft receptor. Biochem Biophys Res Commun. 2007 Oct 5;361(4):829-34
J:135046 Zcharia E, et al., Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models. FASEB J. 2005 Feb;19(2):211-21
J:175154 Brown AJ, et al., Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation. Bone. 2008 Oct;43(4):689-99