Sequence Detail

ID/Version

Q6ZWQ0 Q640M5 (UniProt | EBI)

Last sequence update: 2010-03-23
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Nesprin-2 {ECO:0000305};AltName: Full=KASH domain-containing protein 2; Short=KASH2;AltName: Full=Nuclear envelope spectrin repeat protein 2;AltName: Full=Nucleus and actin connecting element protein; Short=Protein NUANCE;Alt

Provider

SWISS-PROT

Sequence

Polypeptide 6874 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Syne2	spectrin repeat containing, nuclear envelope 2	44	103	3	13

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:139778 Luke Y, et al., Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin. J Cell Sci. 2008 Jun 1;121(Pt 11):1887-98
J:153287 Dawe HR, et al., Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton. J Cell Sci. 2009 Aug 1;122(Pt 15):2716-26
J:155113 Zhang X, et al., SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron. 2009 Oct 29;64(2):173-87
J:168360 Luxton GW, et al., Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement. Science. 2010 Aug 20;329(5994):956-9
J:168852 Yu J, et al., KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. Hum Mol Genet. 2011 Mar 15;20(6):1061-73
J:192230 Razafsky D, et al., LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina. PLoS One. 2012;7(10):e47180
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89