Sequence Detail

ID/Version

Q76JU9 Q8K3T5 A2RS88 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Free fatty acid receptor 1;AltName: Full=G-protein coupled receptor 40;

Provider

SWISS-PROT

Sequence

Polypeptide 300 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ffar1	free fatty acid receptor 1	33	97	3	13

Sequence references in MGI

J:85392 Briscoe CP, et al., The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem. 2003 Mar 28;278(13):11303-11
J:122092 Latour MG, et al., GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes. 2007 Apr;56(4):1087-94
J:141776 Kebede M, et al., The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding. Diabetes. 2008 Sep;57(9):2432-7
J:196896 Wauquier F, et al., The free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation. J Biol Chem. 2013 Mar 1;288(9):6542-51
J:200805 Xiong Y, et al., Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1. Mol Cell Endocrinol. 2013 Apr 30;369(1-2):119-29
J:215962 Yabuki C, et al., A novel antidiabetic drug, fasiglifam/TAK-875, acts as an ago-allosteric modulator of FFAR1. PLoS One. 2013;8(10):e76280