Sequence Detail

ID/Version

Q76MZ3 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;AltName: Full=PP2A subunit A isoform PR65-alpha;AltName: Full=PP2A subunit A isoform R1-alpha;

Provider

SWISS-PROT

Sequence

Polypeptide 589 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ppp2r1a	protein phosphatase 2, regulatory subunit A, alpha	55	107	3	15

Sequence references in MGI

J:62056 Nanahoshi M, et al., Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatases. FEBS Lett. 1999 Mar 5;446(1):108-12
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:185464 Yan L, et al., The B55alpha-containing PP2A holoenzyme dephosphorylates FOXO1 in islet beta-cells under oxidative stress. Biochem J. 2012 Jun 1;444(2):239-47
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:259480 Apostolidis SA, et al., Phosphatase PP2A is requisite for the function of regulatory T cells. Nat Immunol. 2016 May;17(5):556-64
J:266118 Crossthwaite AJ, et al., A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A. Mol Pharmacol. 2006 Feb;69(2):608-17
J:271695 Sonntag T, et al., Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. iScience. 2019 Jan 25;11:134-145
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:305800 Chou WC, et al., AIM2 in regulatory T cells restrains autoimmune diseases. Nature. 2021 Mar;591(7849):300-305