Sequence Detail

ID/Version

Q78IQ7 Q8CHL4 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Zinc transporter ZIP4;AltName: Full=Activated in W/Wv mouse stomach 2; Short=mAWMS2;AltName: Full=Solute carrier family 39 member 4;AltName: Full=Zrt- and Irt-like protein 4; Short=ZIP-4;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 660 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc39a4	solute carrier family 39 (zinc transporter), member 4	30	109	3	21

Sequence references in MGI

J:87294 Dufner-Beattie J, et al., The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice. J Biol Chem. 2003 Aug 29;278(35):33474-81
J:87965 Kim BE, et al., Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane. J Biol Chem. 2004 Feb 6;279(6):4523-30
J:88319 Wang F, et al., Acrodermatitis enteropathica mutations affect transport activity, localization and zinc-responsive trafficking of the mouse ZIP4 zinc transporter. Hum Mol Genet. 2004 Mar 1;13(5):563-71
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:125096 Dufner-Beattie J, et al., The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency. Hum Mol Genet. 2007 Jun 15;16(12):1391-9
J:144552 Kambe T, et al., Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations. Mol Cell Biol. 2009 Jan;29(1):129-39
J:187178 Geiser J, et al., A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity. PLoS Genet. 2012 Jun;8(6):e1002766
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:333973 Chun H, et al., An extracellular histidine-containing motif in the zinc transporter ZIP4 plays a role in zinc sensing and zinc-induced endocytosis in mammalian cells. J Biol Chem. 2019 Feb 22;294(8):2815-2826
J:334009 Weaver BP, et al., Novel zinc-responsive post-transcriptional mechanisms reciprocally regulate expression of the mouse Slc39a4 and Slc39a5 zinc transporters (Zip4 and Zip5). Biol Chem. 2007 Dec;388(12):1301-12