Sequence Detail

ID/Version

Q7TMA4 (UniProt | EBI)

Last sequence update: 2003-10-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Free fatty acid receptor 4;AltName: Full=G-protein coupled receptor 120;AltName: Full=G-protein coupled receptor GT01;AltName: Full=Omega-3 fatty acid receptor 1;

Provider

SWISS-PROT

Sequence

Polypeptide 361 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ffar4	free fatty acid receptor 4	49	100	2	30

Sequence references in MGI

J:95456 Hirasawa A, et al., Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med. 2005 Jan;11(1):90-94
J:99416 Katsuma S, et al., Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1. J Biol Chem. 2005 May 20;280(20):19507-15
J:146309 Matsumura S, et al., Colocalization of GPR120 with phospholipase-Cbeta2 and alpha-gustducin in the taste bud cells in mice. Neurosci Lett. 2009 Jan 30;450(2):186-90
J:161517 Cartoni C, et al., Taste preference for fatty acids is mediated by GPR40 and GPR120. J Neurosci. 2010 Jun 23;30(25):8376-82
J:166091 Oh da Y, et al., GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell. 2010 Sep 3;142(5):687-98
J:182599 Ichimura A, et al., Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature. 2012 Mar 15;483(7389):350-4
J:211675 Stone VM, et al., GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans. Diabetologia. 2014 Jun;57(6):1182-91
J:214106 Suckow AT, et al., Alteration of the glucagon axis in GPR120 (FFAR4) knockout mice: a role for GPR120 in glucagon secretion. J Biol Chem. 2014 May 30;289(22):15751-63
J:221505 Iwasaki K, et al., Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion. Endocrinology. 2015 Mar;156(3):837-46
J:240649 Quesada-Lopez T, et al., The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes. Nat Commun. 2016 Nov 17;7:13479
J:261351 Schilperoort M, et al., The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat. EMBO Mol Med. 2018 Jan 17;
J:282608 Gong Z, et al., G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro. Am J Physiol Endocrinol Metab. 2014 Jan 1;306(1):E28-35
J:282613 Hilgendorf KI, et al., Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis. Cell. 2019 Nov 27;179(6):1289-1305.e21
J:283203 Alvarez-Curto E, et al., Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling. J Biol Chem. 2016 Dec 30;291(53):27147-27159
J:283205 Gao B, et al., GPR120: A bi-potential mediator to modulate the osteogenic and adipogenic differentiation of BMMSCs. Sci Rep. 2015 Sep 14;5:14080