Sequence Detail

ID/Version

Q7TNI7 Q8K4C3 (UniProt | EBI)

Last sequence update: 2003-10-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Interleukin-17F; Short=IL-17F;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 161 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il17f	interleukin 17F	42	96	4	21

Sequence references in MGI

J:115922 Ivanov II, et al., The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 2006 Sep 22;126(6):1121-33
J:143719 Ishigame H, et al., Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity. 2009 Jan;30(1):108-19
J:153022 Kuestner RE, et al., Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. J Immunol. 2007 Oct 15;179(8):5462-73
J:155093 Liang SC, et al., An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment. J Immunol. 2007 Dec 1;179(11):7791-9
J:191712 Gladiator A, et al., Cutting Edge: IL-17-Secreting Innate Lymphoid Cells Are Essential for Host Defense against Fungal Infection. J Immunol. 2013 Jan 15;190(2):521-5
J:251827 De Luca A, et al., The IL-17F/IL-17RC Axis Promotes Respiratory Allergy in the Proximal Airways. Cell Rep. 2017 Aug 15;20(7):1667-1680
J:292764 Hu B, et al., gammadelta T cells and adipocyte IL-17RC control fat innervation and thermogenesis. Nature. 2020 Feb;578(7796):610-614
J:305313 Tang C, et al., Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota. Nat Immunol. 2018 Jul;19(7):755-765