Sequence Detail

ID/Version

Q80U28 Q80W52 Q80WL6 Q6P4I6 Q80WL3 Q80WM2 Q80WM1 Q80WL9 Q80WL7 Q8CBC1 Q80WL8 Q80WL4 Q80WM0 Q3TQK3 Q80WL5 (UniProt | EBI)

Last sequence update: 2007-02-20
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=MAP kinase-activating death domain protein;AltName: Full=Rab3 GDP/GTP exchange factor; Short=RabGEF {ECO:0000305};AltName: Full=Rab3 GDP/GTP exchange protein {ECO:0000303|PubMed:11359932}; Short=Rab3GEP {ECO:0000303|PubMed:11

Provider

SWISS-PROT

Sequence

Polypeptide 1577 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Madd	MAP-kinase activating death domain	29	104	3	6

Sequence references in MGI

J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:126302 Yamaguchi K, et al., A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14536-41
J:126869 Tanaka M, et al., Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction. Mol Biol Cell. 2001 May;12(5):1421-30
J:140259 Figueiredo AC, et al., Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes. J Biol Chem. 2008 Aug 22;283(34):23209-16
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:263424 Niwa S, et al., KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD. Nat Cell Biol. 2008 Nov;10(11):1269-79
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89