Sequence Detail

ID/Version

Q80U70 B1AQE5 Q80Y10 Q99L07 (UniProt | EBI)

Last sequence update: 2003-07-11
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Polycomb protein Suz12;AltName: Full=Suppressor of zeste 12 protein homolog;

Provider

SWISS-PROT

Sequence

Polypeptide 741 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Suz12	SUZ12 polycomb repressive complex 2 subunit	58	116	4	35

Sequence references in MGI

J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:93307 Pasini D, et al., Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 2004 Nov 13;23(20):4061-71
J:94241 Umlauf D, et al., Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. Nat Genet. 2004 Dec;36(12):1296-300
J:122229 Pasini D, et al., The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol. 2007 May;27(10):3769-79
J:129406 Kalantry S, et al., The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation. Nat Cell Biol. 2006 Feb;8(2):195-202
J:142193 Shen X, et al., EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell. 2008 Nov 21;32(4):491-502
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:157068 Walker E, et al., Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Cell Stem Cell. 2010 Feb 5;6(2):153-66
J:201058 Nguyen KD, et al., Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes. Science. 2013 Sep 27;341(6153):1483-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89