Sequence Detail

ID/Version

Q80U72 Q922S3 Q7TPH8 Q8CI48 Q6P5H7 Q80VB1 Q8VII1 (UniProt | EBI)

Last sequence update: 2024-10-02
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Protein scribble homolog {ECO:0000305}; Short=Scribble;AltName: Full=Protein LAP4;

Provider

SWISS-PROT

Sequence

Polypeptide 1665 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Scrib	scribbled planar cell polarity	117	109	3	24

Sequence references in MGI

J:81365 Murdoch JN, et al., Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse. Hum Mol Genet. 2003 Jan 15;12(2):87-98
J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:108647 Montcouquiol M, et al., Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J Neurosci. 2006 May 10;26(19):5265-75
J:140161 Nola S, et al., Scrib regulates PAK activity during the cell migration process. Hum Mol Genet. 2008 Nov 15;17(22):3552-65
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:145314 Yeh JH, et al., Regulation of a late phase of T cell polarity and effector functions by Crtam. Cell. 2008 Mar 7;132(5):846-59
J:152737 Zhan L, et al., Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell. 2008 Nov 28;135(5):865-78
J:153333 Takizawa S, et al., Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. Genes Cells. 2006 Apr;11(4):453-64
J:153473 Sun Y, et al., Scribble interacts with beta-catenin to localize synaptic vesicles to synapses. Mol Biol Cell. 2009 Jul;20(14):3390-400
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87
J:352569 Phua DC, et al., Vimentin regulates scribble activity by protecting it from proteasomal degradation. Mol Biol Cell. 2009 Jun;20(12):2841-55