ID/Version |
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Sequence description from provider |
RecName: Full=Ubiquitin carboxyl-terminal hydrolase 8 {ECO:0000305}; EC=3.4.19.12 {ECO:0000269|PubMed:16120644};AltName: Full=Deubiquitinating enzyme 8;AltName: Full=Ubiquitin isopeptidase Y; Short=mUBPy;AltName: Full=Ubiquitin thioesteras | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
1080
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:68972
Kato M, et al., A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP. J Biol Chem. 2000 Dec 1;275(48):37481-7
J:72190 Gnesutta N, et al., Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1. J Biol Chem. 2001 Oct 19;276(42):39448-54 J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48 J:92790 Wu X, et al., Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. Mol Cell Biol. 2004 Sep;24(17):7748-57 J:107114 Mizuno E, et al., Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes. Mol Biol Cell. 2005 Nov;16(11):5163-74 J:118531 Alwan HA, et al., UBPY-mediated epidermal growth factor receptor (EGFR) de-ubiquitination promotes EGFR degradation. J Biol Chem. 2007 Jan 19;282(3):1658-69 J:122732 Niendorf S, et al., Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo. Mol Cell Biol. 2007 Jul;27(13):5029-39 J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54 J:159711 Berruti G, et al., USP8, a regulator of endosomal sorting, is involved in mouse acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Biol Reprod. 2010 May;82(5):930-9 J:163444 Mizuno E, et al., A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes. Traffic. 2006 Aug;7(8):1017-31 J:193088 Berruti G, et al., The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells. Biol Reprod. 2005 Jan;72(1):14-21 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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