Sequence Detail

ID/Version

Q80UF7 Q3UP66 Q8JZV0 Q3UDB7 Q8CIB7 Q6P6J2 (UniProt | EBI)

Last sequence update: 2003-06-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=TIR domain-containing adapter molecule 1; Short=TICAM-1;AltName: Full=Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; Short=TIR domain-containing adapter protein inducing IFN-beta;

Provider

SWISS-PROT

Sequence

Polypeptide 732 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ticam1	TIR domain containing adaptor molecule 1	106	98	2	22

Sequence references in MGI

J:84679 Yamamoto M, et al., Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 2003 Aug 1;301(5633):640-3
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100715 De Trez C, et al., TLR4 and Toll-IL-1 receptor domain-containing adapter-inducing IFN-beta, but not MyD88, regulate Escherichia coli-induced dendritic cell maturation and apoptosis in vivo. J Immunol. 2005 Jul 15;175(2):839-46
J:144594 Sanada T, et al., FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway. J Biol Chem. 2008 Dec 5;283(49):33858-64
J:173994 Zhang Z, et al., DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells. Immunity. 2011 Jun 24;34(6):866-78
J:224712 Hu YH, et al., WDFY1 mediates TLR3/4 signaling by recruiting TRIF. EMBO Rep. 2015 Apr;16(4):447-55
J:239773 Hu MM, et al., TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms. J Immunol. 2015 Nov 01;195(9):4415-25
J:245346 Oganesyan G, et al., Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature. 2006 Jan 12;439(7073):208-11