Sequence Detail

ID/Version

Q80UG8 Q5U4C4 A4Q9E6 (UniProt | EBI)

Last sequence update: 2006-01-10
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Tubulin monoglutamylase TTLL4 {ECO:0000303|PubMed:17499049}; EC=6.3.2.- {ECO:0000269|PubMed:17499049, ECO:0000269|PubMed:20530212, ECO:0000269|PubMed:21074048, ECO:0000269|PubMed:26829768};AltName: Full=Protein monoglutamylase TTLL4

Provider

SWISS-PROT

Sequence

Polypeptide 1193 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ttll4	tubulin tyrosine ligase-like family, member 4	20	98	3	28

Sequence references in MGI

J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:130247 van Dijk J, et al., A targeted multienzyme mechanism for selective microtubule polyglutamylation. Mol Cell. 2007 May 11;26(3):437-48
J:162689 Lacroix B, et al., Tubulin polyglutamylation stimulates spastin-mediated microtubule severing. J Cell Biol. 2010 Jun 14;189(6):945-54
J:166837 Rogowski K, et al., A family of protein-deglutamylating enzymes associated with neurodegeneration. Cell. 2010 Nov 12;143(4):564-78
J:201638 Bosch Grau M, et al., Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. J Cell Biol. 2013 Aug 5;202(3):441-51
J:231311 Xia P, et al., Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Nat Immunol. 2016 Apr;17(4):369-78
J:259707 Ye B, et al., Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018 Mar 28;9(1):1261