Sequence Detail

ID/Version

Q80VM9 E9QMU2 Q7M735 Q8BRZ4 A0A0R4J1J4 Q8BS22 (UniProt | EBI)

Last sequence update: 2018-03-28
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Proton channel OTOP1 {ECO:0000305};AltName: Full=Otopetrin-1 {ECO:0000303|PubMed:12651873};

Provider

SWISS-PROT

Sequence

Polypeptide 600 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Otop1	otopetrin 1	20	107	3	22

Sequence references in MGI

J:82639 Hurle B, et al., Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1. Hum Mol Genet. 2003 Apr 1;12(7):777-89
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:171290 Kim E, et al., Missense mutations in Otopetrin 1 affect subcellular localization and inhibition of purinergic signaling in vestibular supporting cells. Mol Cell Neurosci. 2011 Mar;46(3):655-61
J:171566 Kim E, et al., Regulation of cellular calcium in vestibular supporting cells by otopetrin 1. J Neurophysiol. 2010 Dec;104(6):3439-50
J:229138 Wang GX, et al., Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation. Diabetes. 2014 Apr;63(4):1340-52
J:259123 Tu YH, et al., An evolutionarily conserved gene family encodes proton-selective ion channels. Science. 2018 Mar 2;359(6379):1047-1050
J:293031 Teng B, et al., Cellular and Neural Responses to Sour Stimuli Require the Proton Channel Otop1. Curr Biol. 2019 Nov 4;29(21):3647-3656.e5
J:293042 Zhang J, et al., Sour Sensing from the Tongue to the Brain. Cell. 2019 Oct 3;179(2):392-402.e15
J:342499 Liang Z, et al., The proton channel OTOP1 is a sensor for the taste of ammonium chloride. Nat Commun. 2023 Oct 5;14(1):6194