Sequence Detail

ID/Version

Q80W65 Q3UEH7 B1AZI4 Q8CFT6 Q8BXW9 (UniProt | EBI)

Last sequence update: 2003-11-07
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Proprotein convertase subtilisin/kexin type 9; EC=3.4.21.-;AltName: Full=Neural apoptosis-regulated convertase 1; Short=NARC-1;AltName: Full=Proprotein convertase 9; Short=PC9;AltName: Full=Subtilisin/kexin-like prote

Provider

SWISS-PROT

Sequence

Polypeptide 694 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pcsk9	proprotein convertase subtilisin/kexin type 9	94	102	3	30

Sequence references in MGI

J:81825 Seidah NG, et al., The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):928-33
J:93102 Maxwell KN, et al., Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice. J Lipid Res. 2003 Nov;44(11):2109-19
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:186176 Sun H, et al., Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor. Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1585-95
J:186215 Kysenius K, et al., PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling. Cell Mol Life Sci. 2012 Jun;69(11):1903-16