Sequence Detail

ID/Version

Q80WG5 A2AQZ0 (UniProt | EBI)

Last sequence update: 2003-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Volume-regulated anion channel subunit LRRC8A {ECO:0000303|PubMed:36522427, ECO:0000303|PubMed:36928458};AltName: Full=Leucine-rich repeat-containing protein 8A {ECO:0000303|PubMed:24752297};AltName: Full=Protein ebouriffe {ECO:0000303|PubMe

Provider

SWISS-PROT

Sequence

Polypeptide 810 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gm28035	predicted gene, 28035	0	96	0	3
Gene	Lrrc8a	leucine rich repeat containing 8A VRAC subunit A	51	98	4	21

Sequence references in MGI

J:34347 Lalouette A, et al., Male sterility caused by sperm cell-specific structural abnormalities in ebouriffe, a new mutation of the house mouse. Biol Reprod. 1996 Aug;55(2):355-63
J:161031 Sawada A, et al., A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans. J Clin Invest. 2003 Dec;112(11):1707-13
J:211308 Kumar L, et al., Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med. 2014 May 5;211(5):929-42
J:258611 Kang C, et al., SWELL1 is a glucose sensor regulating beta-cell excitability and systemic glycaemia. Nat Commun. 2018 Jan 25;9(1):367
J:262352 Deneka D, et al., Structure of a volume-regulated anion channel of the LRRC8 family. Nature. 2018 May 16;
J:263622 Stuhlmann T, et al., LRRC8/VRAC anion channels enhance beta-cell glucose sensing and insulin secretion. Nat Commun. 2018 May 17;9(1):1974
J:265881 Luck JC, et al., LRRC8/VRAC anion channels are required for late stages of spermatid development in mice. J Biol Chem. 2018 Jul 27;293(30):11796-11808
J:266481 Bao J, et al., Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice. JCI Insight. 2018 Aug 23;3(16)
J:272791 Platt CD, et al., Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function. J Allergy Clin Immunol. 2017 Dec;140(6):1651-1659.e1
J:282787 Chen L, et al., The LRRC8/VRAC anion channel facilitates myogenic differentiation of murine myoblasts by promoting membrane hyperpolarization. J Biol Chem. 2019 Sep 27;294(39):14279-14288
J:288504 Zhou C, et al., Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Immunity. 2020 May 19;52(5):767-781.e6
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:296018 Kumar A, et al., SWELL1 regulates skeletal muscle cell size, intracellular signalling, adiposity and glucose metabolism. Elife. 2020 Sep 15;9:e58941
J:322381 Kern DM, et al., Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs. Elife. 2019 Feb 18;8