Sequence Detail

ID/Version

Q80WW9 Q14BT4 Q9CT52 (UniProt | EBI)

Last sequence update: 2003-09-26
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=DDRGK domain-containing protein 1 {ECO:0000305};AltName: Full=UFM1-binding and PCI domain-containing protein 1 {ECO:0000303|PubMed:21494687};

Provider

SWISS-PROT

Sequence

Polypeptide 315 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ddrgk1	DDRGK domain containing 1	69	99	3	24

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:163051 Wu J, et al., A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. J Biol Chem. 2010 May 14;285(20):15126-36
J:217277 Lemaire K, et al., Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. PLoS One. 2011;6(4):e18517
J:231701 Cai Y, et al., UFBP1, a Key Component of the Ufm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation of Erythroid Development. PLoS Genet. 2015 Nov;11(11):e1005643
J:243374 Egunsola AT, et al., Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia. J Clin Invest. 2017 Apr 03;127(4):1475-1484
J:244198 Liu J, et al., A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1alpha stability. Nat Commun. 2017 Jan 27;8:14186
J:274553 Zhu H, et al., Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR. Nat Commun. 2019 Mar 6;10(1):1084
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:298771 Cai Y, et al., Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation. Cell Discov. 2019;5:7
J:347148 Luo H, et al., UFMylation of HRD1 regulates endoplasmic reticulum homeostasis. FASEB J. 2023 Nov;37(11):e23221