Sequence Detail

ID/Version

Q80Y20 Q8BV08 Q9CX44 Q3TUG4 (UniProt | EBI)

Last sequence update: 2003-06-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8; EC=2.1.1.229 {ECO:0000250|UniProtKB:Q96BT7};AltName: Full=Alkylated DNA repair protein alkB homolog 8;AltName: Full=Alpha-ketoglutarate-dependent dioxygenase ALKBH8;AltNam

Provider

SWISS-PROT

Sequence

Polypeptide 664 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Alkbh8	alkB homolog 8, tRNA methyltransferase	31	100	3	11

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:161726 Songe-Moller L, et al., Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding. Mol Cell Biol. 2010 Apr;30(7):1814-27
J:215967 Fu Y, et al., The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA. Angew Chem Int Ed Engl. 2010 Nov 15;49(47):8885-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89