Sequence Detail

ID/Version

Q810S1 Q9CSE7 Q9D345 Q3U4A9 (UniProt | EBI)

Last sequence update: 2003-06-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Calcium uniporter regulatory subunit MCUb, mitochondrial {ECO:0000305}; Short=MCUb {ECO:0000303|PubMed:23900286};AltName: Full=Coiled-coil domain-containing protein 109B {ECO:0000305};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 345 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mcub	mitochondrial calcium uniporter dominant negative beta subunit	26	96	2	12

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:201635 Raffaello A, et al., The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit. EMBO J. 2013 Aug 28;32(17):2362-76
J:298046 Lambert JP, et al., MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress. Circulation. 2019 Nov 19;140(21):1720-1733
J:338466 Feno S, et al., The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration. Sci Signal. 2021 Nov 2;14(707):eabf3838
J:344737 Huo J, et al., MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle. Cell Rep. 2023 Nov 28;42(11):113465