Sequence Detail

ID/Version

Q8BFW3 Q8C390 Q3TC78 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Protein phosphatase 1 regulatory subunit 15B;AltName: Full=Constitutive repressor of eIF2alpha phosphorylation; Short=CReP;

Provider

SWISS-PROT

Sequence

Polypeptide 697 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ppp1r15b	protein phosphatase 1, regulatory subunit 15B	15	97	3	63

Sequence references in MGI

J:86710 Jousse C, et al., Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells. J Cell Biol. 2003 Nov 24;163(4):767-75
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:144954 Harding HP, et al., Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1832-7
J:217282 Latreille M, et al., Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress. J Biol Chem. 2006 Sep 8;281(36):26633-44