Sequence Detail

ID/Version

Q8BGG7 Q8BMW9 Q3U8Z2 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Ubiquitin-associated and SH3 domain-containing protein B; EC=3.1.3.48;AltName: Full=Cbl-interacting protein p70;AltName: Full=Suppressor of T-cell receptor signaling 1; Short=STS-1;AltName: Full=T-cell ubiquitin ligand 2;

Provider

SWISS-PROT

Sequence

Polypeptide 638 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ubash3b	ubiquitin associated and SH3 domain containing, B	38	99	4	9

Sequence references in MGI

J:79606 Carpino N, et al., Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein. Mol Cell Biol. 2002 Nov;22(21):7491-500
J:89761 Carpino N, et al., Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2. Immunity. 2004 Jan;20(1):37-46
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:134815 Mikhailik A, et al., A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling. Mol Cell. 2007 Aug 3;27(3):486-97
J:155244 Carpino N, et al., The Sts proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways. Mol Immunol. 2009 Oct;46(16):3224-31
J:165882 Thomas DH, et al., A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets. Blood. 2010 Oct 7;116(14):2570-8
J:232930 Hu H, et al., Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. J Exp Med. 2016 Mar 7;213(3):399-414
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89