Sequence Detail

ID/Version

Q8BGI3 Q3UAX9 A2RSM6 Q3UX30 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Insulin-induced gene 1 protein {ECO:0000303|PubMed:12242332}; Short=INSIG-1 {ECO:0000303|PubMed:12242332};

Provider

SWISS-PROT

Sequence

Polypeptide 259 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Insig1	insulin induced gene 1	41	100	4	18

Sequence references in MGI

J:79403 Yabe D, et al., Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12753-8
J:84786 Li J, et al., Insig-1 'brakes' lipogenesis in adipocytes and inhibits differentiation of preadipocytes. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9476-81
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101203 Engelking LJ, et al., Schoenheimer effect explained - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest. 2005 Sep;115(9):2489-98
J:114535 Engelking LJ, et al., Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin. J Clin Invest. 2006 Sep;116(9):2356-65
J:224972 Xu D, et al., PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus. Nat Commun. 2015;6:8100