Sequence Detail

ID/Version

Q8BGQ7 Q8BXR0 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Alanine--tRNA ligase, cytoplasmic {ECO:0000255|HAMAP-Rule:MF_03133}; EC=6.1.1.7 {ECO:0000255|HAMAP-Rule:MF_03133, ECO:0000269|PubMed:27622773};AltName: Full=Alanyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_03133}; Short=AlaR

Provider

SWISS-PROT

Sequence

Polypeptide 968 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Aars1	alanyl-tRNA synthetase 1	41	99	3	59

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100999 Giannakopoulos NV, et al., Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. Biochem Biophys Res Commun. 2005 Oct 21;336(2):496-506
J:110647 Lee JW, et al., Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration. Nature. 2006;443(7107):50-5
J:161090 Guo M, et al., Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma. Nature. 2009 Dec 10;462(7274):808-12
J:216802 Liu Y, et al., Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17570-5
J:242411 Sun L, et al., Evolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pair. J Am Chem Soc. 2016 Oct 05;138(39):12948-12955
J:262421 Vo MN, et al., ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase. Nature. 2018 May;557(7706):510-515
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:299134 Zoabi M, et al., Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue. J Biol Chem. 2020 Aug 14;295(33):11822-11832