Sequence Detail

ID/Version

Q8BJQ4 Q3U996 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=TIR domain-containing adapter molecule 2; Short=TICAM-2;AltName: Full=TRIF-related adapter molecule;AltName: Full=Toll/interleukin-1 receptor domain-containing protein;

Provider

SWISS-PROT

Sequence

Polypeptide 232 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ticam2	TIR domain containing adaptor molecule 2	52	97	2	13

Sequence references in MGI

J:84379 Bin LH, et al., TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J Biol Chem. 2003 Jul 4;278(27):24526-32
J:86256 Yamamoto M, et al., TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol. 2003 Nov;4(11):1144-50
J:87175 Oshiumi H, et al., TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem. 2003 Dec 12;278(50):49751-62
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:133314 Kagan JC, et al., TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol. 2008 Apr;9(4):361-8
J:169794 Fitzgerald KA, et al., LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med. 2003 Oct 6;198(7):1043-55
J:196619 Ohnishi H, et al., TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88. PLoS One. 2012;7(6):e38423