Sequence Detail

ID/Version

Q8BWF2 Q549X3 Q501L7 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=GTPase IMAP family member 5;AltName: Full=GTPase of the immunity-associated protein 5 {ECO:0000303|PubMed:16509771};AltName: Full=Immunity-associated nucleotide 4-like 1 protein;AltName: Full=Immunity-associated protein 3;

Provider

SWISS-PROT

Sequence

Polypeptide 308 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gimap5	GTPase, IMAP family member 5	22	96	3	9

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:107746 Nitta T, et al., IAN family critically regulates survival and development of T lymphocytes. PLoS Biol. 2006 Apr;4(4):e103
J:143620 Schulteis RD, et al., Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5. Blood. 2008 Dec 15;112(13):4905-14
J:177305 Chen Y, et al., Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells. J Exp Med. 2011 May 9;208(5):923-35
J:223947 Jokinen R, et al., Quantitative changes in Gimap3 and Gimap5 expression modify mitochondrial DNA segregation in mice. Genetics. 2015 May;200(1):221-35
J:260013 Patterson AR, et al., Gimap5-dependent inactivation of GSK3beta is required for CD4(+) T cell homeostasis and prevention of immune pathology. Nat Commun. 2018 Jan 30;9(1):430
J:355744 Drzewiecki K, et al., GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension. J Exp Med. 2021 Jul 5;218(7)