Sequence Detail

ID/Version

Q8C0J2 Q6KAT7 Q80Y53 Q80U99 Q9DB63 Q80U98 Q80U97 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Autophagy-related protein 16-1 {ECO:0000305};AltName: Full=APG16-like 1 {ECO:0000303|PubMed:18849966};

Provider

SWISS-PROT

Sequence

Polypeptide 607 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Atg16l1	autophagy related 16 like 1	64	97	3	26

Sequence references in MGI

J:83346 Mizushima N, et al., Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J Cell Sci. 2003 May 1;116(Pt 9):1679-88
J:92574 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Apr 30;11(2):127-35
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:141419 Cadwell K, et al., A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature. 2008 Nov 13;456(7219):259-63
J:157879 Travassos LH, et al., Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol. 2010 Jan;11(1):55-62
J:190086 Itoh T, et al., Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. Mol Biol Cell. 2008 Jul;19(7):2916-25
J:200458 Nishimura T, et al., FIP200 regulates targeting of Atg16L1 to the isolation membrane. EMBO Rep. 2013 Mar 1;14(3):284-91
J:203423 Pampliega O, et al., Functional interaction between autophagy and ciliogenesis. Nature. 2013 Oct 10;502(7470):194-200
J:206931 Murthy A, et al., A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. Nature. 2014 Feb 27;506(7489):456-62
J:208987 Sorbara MT, et al., The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner. Immunity. 2013 Nov 14;39(5):858-73
J:211028 Lassen KG, et al., Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7741-6
J:215480 Dooley HC, et al., WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1. Mol Cell. 2014 Jul 17;55(2):238-52
J:245290 Gammoh N, et al., Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy. Nat Struct Mol Biol. 2013 Feb;20(2):144-9
J:289080 Ishibashi K, et al., Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12-5-16L2 complex. Autophagy. 2011 Dec;7(12):1500-13
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:308892 Wang Y, et al., Non-canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virus. EMBO J. 2021 Mar 15;40(6):e105543
J:319693 Zhang Y, et al., SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy. Cell Death Differ. 2021 Mar;28(3):1076-1090
J:335668 Cooney R, et al., NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med. 2010 Jan;16(1):90-7