Sequence Detail

ID/Version

Q8C1E7 Q8BWP7 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transmembrane protein 120A {ECO:0000303|PubMed:26024229};AltName: Full=Ion channel TACAN {ECO:0000303|PubMed:32084332};

Provider

SWISS-PROT

Sequence

Polypeptide 343 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tmem120a	transmembrane protein 120A	16	97	4	12

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:222923 Batrakou DG, et al., TMEM120A and B: Nuclear Envelope Transmembrane Proteins Important for Adipocyte Differentiation. PLoS One. 2015;10(5):e0127712
J:287046 Beaulieu-Laroche L, et al., TACAN Is an Ion Channel Involved in Sensing Mechanical Pain. Cell. 2020 Mar 5;180(5):956-967.e17
J:321295 Czapiewski R, et al., Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy. Nat Commun. 2022 Jan 13;13(1):321
J:322824 Li S, et al., Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation. Nat Commun. 2022 Jan 10;13(1):105
J:326278 Malik P, et al., Cell-specific and lamin-dependent targeting of novel transmembrane proteins in the nuclear envelope. Cell Mol Life Sci. 2010 Apr;67(8):1353-69
J:355639 Niu Y, et al., Analysis of the mechanosensor channel functionality of TACAN. Elife. 2021 Aug 10;10
J:357150 Parpaite T, et al., Patch-seq of mouse DRG neurons reveals candidate genes for specific mechanosensory functions. Cell Rep. 2021 Nov 2;37(5):109914