Sequence Detail

ID/Version

Q8C419 B1AWY4 Q8CHB0 (UniProt | EBI)

Last sequence update: 2005-06-07
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Metabotropic glycine receptor {ECO:0000303|PubMed:36996198}; Short=mGlyR {ECO:0000303|PubMed:36996198};AltName: Full=G-protein coupled receptor 158 {ECO:0000305};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1200 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gpr158	G protein-coupled receptor 158	34	105	4	6

Sequence references in MGI

J:86755 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2002 Oct 31;9(5):179-88
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:185272 Orlandi C, et al., GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes. J Cell Biol. 2012 Jun 11;197(6):711-9
J:232911 Orlandi C, et al., Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain. J Biol Chem. 2015 May 29;290(22):13622-39
J:246056 Khrimian L, et al., Gpr158 mediates osteocalcin's regulation of cognition. J Exp Med. 2017 Oct 02;214(10):2859-2873
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:263624 Sutton LP, et al., Orphan receptor GPR158 controls stress-induced depression. Elife. 2018 Feb 8;7:e33273
J:268760 Condomitti G, et al., An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses. Neuron. 2018 Oct 10;100(1):201-215.e9
J:269858 Orlandi C, et al., Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors. Cell Rep. 2018 Oct 2;25(1):130-145.e5
J:270826 Kosmidis S, et al., RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss. Cell Rep. 2018 Oct 23;25(4):959-973.e6
J:278859 Orlandi C, et al., Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors. Neuropsychopharmacology. 2019 Feb;44(3):642-653
J:280560 Itakura T, et al., GPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure. J Ocul Pharmacol Ther. 2019 May;35(4):203-215
J:281109 Song C, et al., The signaling proteins GPR158 and RGS7 modulate excitability of L2/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex. J Biol Chem. 2019 Aug 30;294(35):13145-13157
J:284579 Cetereisi D, et al., Gpr158 Deficiency Impacts Hippocampal CA1 Neuronal Excitability, Dendritic Architecture, and Affects Spatial Learning. Front Cell Neurosci. 2019;13:465
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:335122 Laboute T, et al., Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR. Science. 2023 Mar 31;379(6639):1352-1358
J:337406 Chang J, et al., Expression Mapping and Functional Analysis of Orphan G-Protein-Coupled Receptor GPR158 in the Adult Mouse Brain Using a GPR158 Transgenic Mouse. Biomolecules. 2023 Mar 5;13(3)