Sequence Detail

ID/Version

Q8C6A8 Q9JL05 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Class E basic helix-loop-helix protein 22; Short=bHLHe22;AltName: Full=Class B basic helix-loop-helix protein 5; Short=bHLHb5;AltName: Full=Protein BETA3;

Provider

SWISS-PROT

Sequence

Polypeptide 355 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Bhlhe22	basic helix-loop-helix family, member e22	29	122	3	7

Sequence references in MGI

J:78916 Xu ZP, et al., Functional and structural characterization of the human gene BHLHB5, encoding a basic helix-loop-helix transcription factor. Genomics. 2002 Sep;80(3):311-8
J:86963 Brunelli S, et al., Bhlhb5 is expressed in the CNS and sensory organs during mouse embryonic development. Gene Expr Patterns. 2003 Dec;3(6):755-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:119663 Feng L, et al., Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina. Development. 2006 Dec;133(24):4815-25
J:144066 Joshi PS, et al., Bhlhb5 regulates the postmitotic acquisition of area identities in layers II-V of the developing neocortex. Neuron. 2008 Oct 23;60(2):258-72
J:158273 Ross SE, et al., Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron. 2010 Mar 25;65(6):886-98
J:182304 Ross SE, et al., Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly. Neuron. 2012 Jan 26;73(2):292-303