Sequence Detail

ID/Version

Q8CA72 (UniProt | EBI)

Last sequence update: 2008-12-16
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Gigaxonin {ECO:0000312|MGI:MGI:1890619};

Provider

SWISS-PROT

Sequence

Polypeptide 597 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gan	giant axonal neuropathy	13	102	3	16

Sequence references in MGI

J:78266 Ding J, et al., Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin. J Cell Biol. 2002 Aug 5;158(3):427-33
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:102767 Allen E, et al., Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival. Nature. 2005 Nov 10;438(7065):224-8
J:108239 Ding J, et al., Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport. Hum Mol Genet. 2006 May 1;15(9):1451-63
J:140136 Dequen F, et al., Modest loss of peripheral axons, muscle atrophy and formation of brain inclusions in mice with targeted deletion of gigaxonin exon 1. J Neurochem. 2008 Oct;107(1):253-64