Sequence Detail

ID/Version

Q8CE90 Q9R1Z6 O54780 O70242 Q8BSP1 O35406 Q9R1Z4 O35872 O35871 Q9R1Z3 Q9QWG6 O70243 O35720 Q9R1Z5 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Dual specificity mitogen-activated protein kinase kinase 7; Short=MAP kinase kinase 7; Short=MAPKK 7; EC=2.7.12.2 {ECO:0000269|PubMed:9535930, ECO:0000269|PubMed:9891090};AltName: Full=JNK-activating kinase 2;AltName:

Provider

SWISS-PROT

Sequence

Polypeptide 535 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Map2k7	mitogen-activated protein kinase kinase 7	59	102	3	11

Sequence references in MGI

J:43260 Holland PM, et al., MKK7 is A stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous. J Biol Chem. 1997 Oct 3;272(40):24994-8
J:44734 Yao Z, et al., Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase. J Biol Chem. 1997 Dec 19;272(51):32378-83
J:45847 Moriguchi T, et al., A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses. EMBO J. 1997 Dec 1;16(23):7045-53
J:46958 Foltz IN, et al., Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli. J Biol Chem. 1998 Apr 10;273(15):9344-51
J:52243 Tournier C, et al., The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases. Mol Cell Biol. 1999 Feb;19(2):1569-81
J:59878 Kelkar N, et al., Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. Mol Cell Biol. 2000 Feb;20(3):1030-43
J:83279 Kishimoto H, et al., Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. J Biol Chem. 2003 May 9;278(19):16595-601
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:205863 Cunningham CA, et al., The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals and effector function in CD8(+) T cells. Eur J Immunol. 2013 Dec;43(12):3361-71
J:261832 Cunningham CA, et al., POSH Regulates CD4+ T Cell Differentiation and Survival. J Immunol. 2016 May 15;196(10):4003-13