Sequence Detail

ID/Version

Q8CFB4 Q8CFA4 E9QJR4 Q8CFA8 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Guanylate-binding protein 5; EC=3.6.5.- {ECO:0000250|UniProtKB:Q96PP8};AltName: Full=GTP-binding protein 5 {ECO:0000303|PubMed:12396730}; Short=GBP-5 {ECO:0000303|PubMed:12396730}; Short=MuGBP-5;AltName: Full=Guanine

Provider

SWISS-PROT

Sequence

Polypeptide 590 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gbp5	guanylate binding protein 5	52	96	6	15

Sequence references in MGI

J:86367 Nguyen TT, et al., Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro. J Interferon Cytokine Res. 2002 Aug;22(8):899-909
J:155210 Degrandi D, et al., Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. J Immunol. 2007 Dec 1;179(11):7729-40
J:183942 Shenoy AR, et al., GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Science. 2012 Apr 27;336(6080):481-5
J:208845 Pilla DM, et al., Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6046-51
J:210626 Meunier E, et al., Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Nature. 2014 May 15;509(7500):366-70
J:231713 Meunier E, et al., Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida. Nat Immunol. 2015 May;16(5):476-84
J:231714 Man SM, et al., The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection. Nat Immunol. 2015 May;16(5):467-75
J:236523 Man SM, et al., IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes. Cell. 2016 Oct 6;167(2):382-396.e17
J:333171 Cerqueira DM, et al., Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection. PLoS Pathog. 2018 Dec;14(12):e1007519