Sequence Detail

ID/Version

Q8CI19 Q99JM4 Q9JHV8 Q9QY71 (UniProt | EBI)

Last sequence update: 2008-07-22
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Platelet-derived growth factor C; Short=PDGF-C;AltName: Full=Fallotein;AltName: Full=Spinal cord-derived growth factor; Short=SCDGF;AltName: Full=VEGF-E;Contains: RecName: Full=Platelet-derived growth factor C, latent form;

Provider

SWISS-PROT

Sequence

Polypeptide 345 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pdgfc	platelet-derived growth factor, C polypeptide	38	114	3	24

Sequence references in MGI

J:62052 Li X, et al., PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor [see comments]. Nat Cell Biol. 2000 May;2(5):302-9
J:64341 Ding H, et al., The mouse pdgfc gene: dynamic expression in embryonic tissues during organogenesis. Mech Dev. 2000 Sep;96(2):209-13
J:70550 Gilbertson DG, et al., Platelet-derived Growth Factor C (PDGF-C), a Novel Growth Factor That Binds to PDGF alpha and beta Receptor. J Biol Chem. 2001 Jul 20;276(29):27406-14
J:73808 Aase K, et al., Expression analysis of PDGF-C in adult and developing mouse tissues. Mech Dev. 2002 Jan;110(1-2):187-91
J:84525 Ponten A, et al., Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy. Am J Pathol. 2003 Aug;163(2):673-82
J:93392 Fredriksson L, et al., Tissue plasminogen activator is a potent activator of PDGF-CC. EMBO J. 2004 Sep 29;23(19):3793-802
J:93954 Ding H, et al., A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat Genet. 2004 Oct;36(10):1111-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:107894 Reigstad LJ, et al., Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines. Exp Cell Res. 2006 Apr 1;312(6):782-95
J:129217 Chen X, et al., Aberrant expression of PDGF ligands and receptors in the tumor prone ovary of follitropin receptor knockout (FORKO) mouse. Carcinogenesis. 2006 May;27(5):903-15
J:138041 Ingram JL, et al., Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts. J Immunol. 2006 Sep 15;177(6):4141-8
J:149932 Eitner F, et al., PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis. J Am Soc Nephrol. 2008 Feb;19(2):281-9