Sequence Detail

ID/Version

Q8CIG8 Q3TNN1 Q9QZS9 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Protein arginine N-methyltransferase 5; Short=Prmt5; EC=2.1.1.320 {ECO:0000269|PubMed:28263986};AltName: Full=Histone-arginine N-methyltransferase PRMT5;AltName: Full=Jak-binding protein 1;AltName: Full=Shk1 kinase-binding pr

Provider

SWISS-PROT

Sequence

Polypeptide 637 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prmt5	protein arginine N-methyltransferase 5	83	102	3	25

Sequence references in MGI

J:58151 Pollack BP, et al., The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity. J Biol Chem. 1999 Oct 29;274(44):31531-42
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:109626 Ancelin K, et al., Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. Nat Cell Biol. 2006 Jun;8(6):623-30
J:151086 Vagin VV, et al., Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev. 2009 Aug 1;23(15):1749-62
J:156247 van Dijk TB, et al., Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases. Mol Cell Biol. 2010 Jan;30(1):260-72
J:192252 Na J, et al., Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene. PLoS One. 2012;7(10):e48152
J:196248 Paul C, et al., The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation. Cell Death Differ. 2012 May;19(5):900-8
J:242066 Akpinar M, et al., TDRD6 mediates early steps of spliceosome maturation in primary spermatocytes. PLoS Genet. 2017 Mar;13(3):e1006660
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89