Sequence Detail

ID/Version

Q8CJG0 A1A563 Q571J6 Q4VAB3 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Protein argonaute-2 {ECO:0000255|HAMAP-Rule:MF_03031}; Short=Argonaute2 {ECO:0000255|HAMAP-Rule:MF_03031}; Short=mAgo2; EC=3.1.26.n2 {ECO:0000255|HAMAP-Rule:MF_03031};AltName: Full=Argonaute RISC catalytic component 2

Provider

SWISS-PROT

Sequence

Polypeptide 860 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ago2	argonaute RISC catalytic subunit 2	130	105	3	34

Sequence references in MGI

J:92289 Doi N, et al., Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. Curr Biol. 2003 Jan 8;13(1):41-6
J:93081 Liu J, et al., Argonaute2 is the catalytic engine of mammalian RNAi. Science. 2004 Sep 3;305(5689):1437-41
J:144999 Su H, et al., Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Dev. 2009 Feb 1;23(3):304-17
J:158290 Rybak A, et al., The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat Cell Biol. 2009 Dec;11(12):1411-20
J:165967 O'Carroll D, et al., A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes Dev. 2007 Aug 15;21(16):1999-2004
J:183920 Chen J, et al., The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes Dev. 2012 Apr 15;26(8):803-15
J:190251 Chang HM, et al., Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun. 2012;3:923
J:211330 Milochau A, et al., Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic beta-cells. FEBS Lett. 2014 Jun 27;588(14):2217-22
J:217997 Maniataki E, et al., A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. Genes Dev. 2005 Dec 15;19(24):2979-90
J:221791 Srivastava M, et al., Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis. Nat Commun. 2015;6:6253
J:260599 Belanger C, et al., Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E620-E629
J:277871 Xu M, et al., Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929. Biochem Biophys Res Commun. 2015 Jul 31;463(3):275-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89