Sequence Detail

ID/Version

Q8K120 B5B2X2 Q3TXW7 Q9EP91 (UniProt | EBI)

Last sequence update: 2009-03-24
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Nuclear factor of activated T-cells, cytoplasmic 4 {ECO:0000250|UniProtKB:Q14934}; Short=NF-ATc4 {ECO:0000250|UniProtKB:Q14934}; Short=NFATc4 {ECO:0000303|PubMed:18354019};AltName: Full=T-cell transcription factor NFAT3 {ECO:

Provider

SWISS-PROT

Sequence

Polypeptide 901 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nfatc4	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4	71	110	3	8

Sequence references in MGI

J:79608 Wilkins BJ, et al., Targeted Disruption of NFATc3, but Not NFATc4, Reveals an Intrinsic Defect in Calcineurin-Mediated Cardiac Hypertrophic Growth. Mol Cell Biol. 2002 Nov;22(21):7603-13
J:84138 Bushdid PB, et al., NFATc3 and NFATc4 are required for cardiac development and mitochondrial function. Circ Res. 2003 Jun 27;92(12):1305-13
J:93176 Molkentin JD, et al., A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell. 1998 May 17;93(2):215-28
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:119549 Yang XY, et al., Dosage-dependent transcriptional regulation by the calcineurin/NFAT signaling in developing myocardium transition. Dev Biol. 2007 Mar 15;303(2):825-37
J:133209 Luoma JI, et al., Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS. J Neurosci. 2008 Mar 19;28(12):3159-69
J:139569 Wang D, et al., The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT. Mol Immunol. 2008 Sep;45(15):3902-8
J:141917 Cante-Barrett K, et al., Selective role of NFATc3 in positive selection of thymocytes. J Immunol. 2007 Jul 1;179(1):103-10
J:141959 Vihma H, et al., Alternative splicing and expression of human and mouse NFAT genes. Genomics. 2008 Nov;92(5):279-91
J:169854 Reddy RN, et al., Rescue of Calcineurin Aalpha(-/-) Mice Reveals a Novel Role for the alpha Isoform in the Salivary Gland. Am J Pathol. 2011 Apr;178(4):1605-13
J:184759 Quadrato G, et al., Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):E1499-508
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:343111 Ranjan R, et al., The transcription factor nuclear factor of activated T cells c3 modulates the function of macrophages in sepsis. J Innate Immun. 2014;6(6):754-64
J:343388 Manukyan I, et al., Cross-talk between calcineurin/NFAT and Jak/STAT signalling induces cardioprotective alphaB-crystallin gene expression in response to hypertrophic stimuli. J Cell Mol Med. 2010 Jun;14(6B):1707-16